Description

Hydrocortisone 21-Carboxylic Acid is a key pharmaceutical intermediate and a derivative of the natural glucocorticoid hormone hydrocortisone. This compound is of significant value for the synthesis of more potent and specialized corticosteroid APIs, enabling precise chemical modifications. It is primarily required by pharmaceutical R&D laboratories and manufacturers engaged in the production of advanced topical and systemic anti-inflammatory medications.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel and high-potency corticosteroid active pharmaceutical ingredients (APIs).
• Steroid Derivative Synthesis: Used in research and production to create esterified or otherwise modified forms of hydrocortisone with tailored pharmacokinetic properties.
• Reference Standard: Serves as a high-purity analytical standard in quality control laboratories for method development and validation.
• Biochemical Research: Employed in studies investigating glucocorticoid receptor interactions, metabolic pathways, and steroid hormone chemistry.
• Veterinary Pharmaceutical Development: Used in formulating anti-inflammatory treatments for animal health applications.

Basic Information

Product Name	Hydrocortisone 21-Carboxylic Acid
CAS No.	57172-48-2
Molecular Formula	C22H30O6
Molecular Weight	390.47 g/mol
Synonyms	11β,17α,21-Trihydroxypregn-4-ene-3,20-dione-21-carboxylic acid; Cortisol-21-carboxylic acid; Hydrocortisone-21-carboxylic acid; 21-Carboxycortisol; (11β)-11,17,21-Trihydroxypregn-4-ene-3,20-dione-21-carboxylic acid; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, 21-carboxy-, (11β)-
EINECS	Contact for details

Quality Control

Our Hydrocortisone 21-Carboxylic Acid is produced and tested under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the stringent requirements for pharmaceutical intermediate use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.