Description

(R)-Penbutolol Hydrochloride is the single enantiomer form of the non-selective β-adrenergic blocking agent, penbutolol. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the study of stereospecific drug activity and metabolism. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the development of cardiovascular therapeutics and advanced chiral synthesis.

Application

• Pharmaceutical Active Ingredient (API) Intermediate: Key chiral building block in the synthesis of enantiomerically pure β-blocker medications.
• Cardiovascular Research: Used in preclinical and clinical studies to investigate the pharmacological profile, efficacy, and safety of the (R)-enantiomer.
• Chiral Reference Standard: Serves as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical labs.
• Metabolite Studies: Employed in research to understand the stereoselective metabolism and pharmacokinetics of penbutolol.
• Process Chemistry & Development: Used to optimize and scale up asymmetric synthesis routes for β-adrenergic antagonists.

Basic Information

Product Name	(R)-Penbutolol Hydrochloride
CAS No.	57130-27-5
Molecular Formula	C18H30ClNO3
Molecular Weight	343.89 g/mol
Synonyms	(R)-Penbutolol HCl; (R)-1-(tert-Butylamino)-3-(2-cyclopentylphenoxy)-2-propanol Hydrochloride; (2R)-1-(1,1-Dimethylethyl)amino-3-(2-cyclopentylphenoxy)-2-propanol Hydrochloride; Levopenbutolol Hydrochloride; (R)-(−)-Penbutolol Hydrochloride; Dexpenbutolol Hydrochloride; CAS 57130-27-5
EINECS	Contact for details

Quality Control

Our (R)-Penbutolol Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including chiral purity assay, identification, and impurity profiling to ensure it meets exacting standards for pharmaceutical research. Certificates of Analysis (COA) with detailed HPLC/GC data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Chiral Purity (HPLC)	≥99.0% (R)-enantiomer
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.