Description

Methyl Prednisolonate CAS NO 57072-99-8 is a key pharmaceutical intermediate and steroid derivative, essential for the synthesis of potent glucocorticoids. Its primary value lies in its role as a precursor in the production of high-purity active pharmaceutical ingredients (APIs) for anti-inflammatory and immunosuppressive medications. This compound is critically needed by pharmaceutical manufacturers, research institutions, and fine chemical synthesis facilities focused on developing and producing corticosteroid-based therapies.

Application

• Pharmaceutical Intermediate: Primary use as a crucial building block in the synthesis of Methylprednisolone and related corticosteroid APIs.
• Anti-inflammatory Drug Production: Serves as a key precursor in manufacturing injectable and oral formulations for treating severe inflammation and autoimmune conditions.
• Research & Development: Used in medicinal chemistry research for developing new steroid-based therapeutics with modified potency and pharmacokinetic profiles.
• Fine Chemical Synthesis: Employed in custom synthesis and process development for high-value steroid compounds in contract manufacturing organizations (CMOs).
• Reference Standard: Utilized as an analytical standard in quality control laboratories for HPLC and spectroscopic method development and validation.

Basic Information

Item	Detail
Product Name	Methyl Prednisolonate
CAS No.	57072-99-8
Molecular Formula	C22H30O5
Molecular Weight	374.47 g/mol
Synonyms	11β,17α,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-acetate; 6α-Methylprednisolone 21-acetate; 21-Acetoxy-6α-methylprednisolone; Methylprednisolone acetate intermediate; 6α-Methyl-δ1-hydrocortisone acetate; 6-Methylprednisolone 21-acetate; 6α-Methylprednisolonate
EINECS	Contact for details

Quality Control

Our Methyl Prednisolonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with cGMP and relevant pharmaceutical intermediate standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.