Description

2-(Difluoromethoxy)Benzonitrile is a versatile fluorinated aromatic nitrile building block, valued for its unique difluoromethoxy substituent which imparts enhanced metabolic stability and lipophilicity to target molecules. This compound is essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where the introduction of fluorine atoms is a key strategy for optimizing biological activity. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) drugs and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group enhances efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies.
• Organic Electronics: Employed as a building block for electron-transport materials and other functional components in OLEDs and organic semiconductors.
• Cross-Coupling Reactions: The nitrile and aromatic halide functionalities make it a valuable substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Chemical Research & Development: A versatile reagent for exploring new fluorination methodologies and creating novel chemical entities in academic and industrial labs.

Basic Information

Product Name	2-(Difluoromethoxy)Benzonitrile
CAS No.	56935-78-5
Molecular Formula	C8H5F2NO
Molecular Weight	169.13 g/mol
Synonyms	2-(Difluoromethoxy)benzonitrile; o-(Difluoromethoxy)benzonitrile; Benzonitrile, 2-(difluoromethoxy)-; 2-Difluoromethoxybenzonitrile; 1-Cyano-2-(difluoromethoxy)benzene; Difluoromethoxybenzonitrile; 56935-78-5
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our commitment to cGMP and ISO standards ensures reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.