Description

9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21-Nonanoate is a synthetic corticosteroid ester, specifically a 21-nonanoate derivative of a fluorinated pregnadiene. This compound is valued for its potent anti-inflammatory and immunosuppressive properties, which are modulated by the specific esterification at the 21-position, influencing its pharmacokinetic profile. It is primarily utilized in advanced pharmaceutical research and development, particularly for creating novel topical and injectable corticosteroid formulations targeting dermatological and inflammatory conditions.

Application

• Pharmaceutical Intermediate: Key starting material or advanced intermediate in the synthesis of potent corticosteroid APIs (Active Pharmaceutical Ingredients).
• Topical Corticosteroid R&D: Research into new creams, ointments, and lotions for treating eczema, psoriasis, and dermatitis.
• Injectable Steroid Formulations: Development of long-acting depot injections for managing chronic inflammatory and autoimmune disorders.
• Veterinary Medicine: Potential use in developing anti-inflammatory treatments for animals.
• Biochemical Research: Tool compound for studying glucocorticoid receptor interactions and steroid metabolism pathways.
• Process Chemistry & Scale-Up: Serves as a critical reference standard and material for process optimization and validation in GMP manufacturing.

Basic Information

Product Name	9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21-Nonanoate
CAS No.	56933-62-1
Molecular Formula	C₃₁H₄₅FO₆
Molecular Weight	520.70 g/mol
Synonyms	Flumethasone 21-Nonanoate; Flumethasone Pivalate (common misnomer); 9α-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-nonanoate; 16β-Methyl-9α-fluoroprednisolone 21-nonanoate; NSC 107679; Flumethasone 21-nonoate; Flumetasone 21-nonanoate; Flumethasone Caprylate (historical).
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21-Nonanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.