Description

9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21-Hexanoate is a high-purity synthetic corticosteroid derivative, specifically a 21-hexanoate ester prodrug of a fluorinated glucocorticoid. This compound is valued for its enhanced lipophilicity and modified pharmacokinetic profile compared to its parent molecule, offering controlled release and targeted activity. It is primarily utilized in advanced pharmaceutical research and development for creating novel topical and systemic anti-inflammatory formulations.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel, potent corticosteroid APIs (Active Pharmaceutical Ingredients).
• Topical Formulation R&D: Research into creams, ointments, and gels for treating dermatological conditions like eczema, psoriasis, and contact dermatitis.
• Prodrug Development: Used in studies to improve drug delivery, bioavailability, and duration of action through esterification.
• Anti-inflammatory Agent Research: Investigation of mechanisms and efficacy in models of inflammation and immune response.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.
• Veterinary Pharmaceutical Development: Potential application in developing anti-inflammatory treatments for animals.

Basic Information

Product Name	9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21-Hexanoate
CAS No.	56933-61-0
Molecular Formula	C28H39FO6
Molecular Weight	490.61 g/mol
Synonyms	Flumethasone 21-Hexanoate; Flumethasone Pivalate (common misnomer); 9α-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-hexanoate; 16β-Methyl-9α-fluoroprednisolone 21-hexanoate; NSC 107679; SQ 15102; Flumethasone 21-Caproate; Flumetasone 21-hexanoate
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21-Hexanoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with cGMP standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.