Description

16-Methylene-11α,17,21-Tris[(Trifluoroacetyl)Oxy]-5α-Pregnane-3,20-Dione is a high-purity synthetic steroid derivative, specifically a trifluoroacetylated pregnane dione, which serves as a critical advanced pharmaceutical intermediate (API) in modern organic synthesis. Its value lies in its role as a key building block for the research and development of novel steroidal compounds with potential therapeutic applications. This compound is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of fine chemicals and reference standards.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel corticosteroid analogs and other bioactive steroidal molecules.
• Research & Development: Used in academic and industrial laboratories for investigating new synthetic pathways and structure-activity relationships (SAR) in medicinal chemistry.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis using HPLC, GC-MS, or NMR.
• Process Chemistry: Employed in scaling up synthetic routes for the production of target steroid-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Utilized in studies exploring enzyme inhibition, receptor binding, and metabolic pathways involving steroidal frameworks.

Basic Information

Product Name	16-Methylene-11α,17,21-Tris[(Trifluoroacetyl)Oxy]-5α-Pregnane-3,20-Dione
CAS No.	56438-16-5
Molecular Formula	C30H34F9O8
Molecular Weight	678.58 g/mol
Synonyms	16-Methylene-11α,17α,21-trihydroxypregn-4-ene-3,20-dione 11,17,21-tris(trifluoroacetate); 5α-Pregnane-3,20-dione, 16-methylene-11α,17,21-tris[(trifluoroacetyl)oxy]-; 11β,17α,21-Trihydroxy-16-methylenepregna-4-ene-3,20-dione 11,17,21-Tris(trifluoroacetate); Trifluoroacetylated 16-Methylene Prednisolone Derivative; 16-Methylene Prednisolone 11,17,21-Tris(trifluoroacetate)
EINECS	Contact for details

Quality Control

Our 16-Methylene-11α,17,21-Tris[(Trifluoroacetyl)Oxy]-5α-Pregnane-3,20-Dione is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurities is provided with each shipment to ensure it meets the stringent requirements for pharmaceutical R&D and reference standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound may be sensitive to moisture; keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.