Description

Metoprolol Hydrochloride is a selective β-1 adrenergic receptor blocking agent, a crucial active pharmaceutical ingredient (API) in cardiovascular medicine. Its primary value lies in its efficacy for managing hypertension, angina pectoris, and heart failure, offering reliable therapeutic outcomes. This high-purity compound is essential for pharmaceutical manufacturers and research institutions globally, serving as the core component in tablet, capsule, and extended-release formulations.

Application

• Pharmaceutical API: Primary use in the manufacture of finished dosage forms for cardiovascular diseases.
• Hypertension Treatment: Key ingredient in antihypertensive medications to lower blood pressure.
• Angina Pectoris Management: Used in formulations to prevent chest pain caused by reduced blood flow to the heart.
• Heart Failure Therapy: Incorporated into treatment regimens to improve survival and reduce hospitalizations.
• Clinical Research: Serves as a reference standard and raw material for pharmacokinetic and pharmacodynamic studies.
• Generic Drug Production: A fundamental component for companies developing bioequivalent generic versions of branded metoprolol products.

Basic Information

Product Name	Metoprolol Hydrochloride
CAS No.	56392-18-8
Molecular Formula	C15H25NO3 • HCl
Molecular Weight	303.82 g/mol (as hydrochloride salt)
Synonyms	Metoprolol HCl; (±)-Metoprolol Hydrochloride; 1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol Hydrochloride; Lopressor® (brand name); Toprol-XL® (brand name); Betaloc® (brand name); Seloken® (brand name); CGP 2175
EINECS	Contact for details

Quality Control

Our Metoprolol Hydrochloride is manufactured under strict quality systems, targeting compliance with major pharmacopoeial standards such as USP, EP, and JP. Each batch undergoes rigorous analytical testing including assay, related substances, residual solvents, and microbiological examination to ensure identity, strength, purity, and quality. A comprehensive Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The container should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.2% Total impurities: NMT 1.0%
Water (KF)	NMT 0.5%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Microbial Enumeration	Meets EP/USP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.