Description

5,6-Difluoro-3β-Hydroxypregnan-20-One is a high-purity, fluorinated pregnane derivative, a key intermediate in advanced pharmaceutical synthesis. This compound is valued for its role in the development of novel steroid-based therapeutics, where its specific fluorination pattern can significantly alter biological activity and metabolic stability. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of next-generation hormonal treatments, anti-inflammatory agents, and other specialized steroid molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel fluorinated corticosteroid and progestin analogs.
• Steroid Research: Used in academic and industrial R&D to study structure-activity relationships (SAR) in steroid hormone receptors.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in steroid analysis.
• Process Chemistry: Employed in route scouting and optimization for the commercial-scale production of complex steroid APIs.
• Biochemical Tool: Utilized in biochemical assays to investigate enzyme inhibition or modulation related to steroid metabolism.

Basic Information

Product Name	5,6-Difluoro-3β-Hydroxypregnan-20-One
CAS No.	56193-66-9
Molecular Formula	C₂₁H₃₀F₂O₂
Molecular Weight	352.46 g/mol
Synonyms	5,6-Difluoro-3β-hydroxypregnan-20-one; 5,6-Difluoro-3β-hydroxy-20-oxopregnane; 20-Oxo-5,6-difluoro-3β-pregnan-3-ol; Pregnan-20-one, 5,6-difluoro-3β-hydroxy-; 3β-Hydroxy-5,6-difluoropregnan-20-one
EINECS	Contact for details

Quality Control

Our 5,6-Difluoro-3β-Hydroxypregnan-20-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.