Description

Valrubicin is a semi-synthetic anthracycline antineoplastic agent, specifically a derivative of doxorubicin. This compound is of significant commercial and clinical interest due to its targeted mechanism of action and application in specialized oncology treatments. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of advanced chemotherapeutic formulations.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active component in the formulation of intravesical chemotherapy for the treatment of BCG-refractory carcinoma in situ (CIS) of the urinary bladder.
• Oncology Research: A critical reference standard and investigational compound in cancer research, particularly for studying anthracycline pharmacology, drug resistance mechanisms, and novel drug delivery systems.
• Drug Development: Serves as a key intermediate or model compound in the R&D of new anthracycline-based therapies with improved efficacy and reduced cardiotoxicity profiles.
• Biochemical Studies: Used in laboratory studies to investigate topoisomerase II inhibition, apoptosis induction, and cellular uptake mechanisms in various cancer cell lines.

Basic Information

Product Name	Valrubicin
CAS No.	56124-62-0
Molecular Formula	C34H36F3NO13
Molecular Weight	723.65 g/mol
Synonyms	N-Trifluoroacetyladriamycin-14-valerate; AD 32; Valstar; NSC 246131; (2S-cis)-2-[1,2,3,4,6,11-Hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-[[2,3,6-trideoxy-3-[(trifluoroacetyl)amino]-α-L-lyxo-hexopyranosyl]oxy]-2-naphthacenyl]-2-oxoethyl pentanoate; Trifluoroacetyladriamycin-14-valerate
EINECS	Contact for details

Quality Control

Our Valrubicin is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical intermediates and reference standards. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and specifications are designed to align with pharmacopeial standards for related anthracycline compounds.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	Orange to red-orange powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.