Description

Pregna-1,4-Dien-3-One, 9-Fluoro-11,17,20,21-Tetrahydroxy-16-Methyl-, (11β,16α)- (9Ci) is a high-purity synthetic corticosteroid intermediate of significant pharmaceutical importance. This compound serves as a critical building block in the synthesis of potent anti-inflammatory and immunosuppressive steroid APIs, valued for its precise stereochemistry and functional groups. It is essential for manufacturers in the pharmaceutical and fine chemical sectors requiring reliable, high-quality raw materials for advanced steroid production.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of advanced corticosteroid active pharmaceutical ingredients (APIs).
• Anti-inflammatory Drug Development: Used in research and production of medications targeting inflammation, allergies, and autoimmune disorders.
• Steroid Synthesis: Integral for constructing complex steroid molecules with specific fluorinated and hydroxylated configurations.
• Biochemical Research: Employed as a reference standard or reagent in steroid metabolism and receptor binding studies.
• Veterinary Medicine: Used in the development of anti-inflammatory treatments for animals.
• Fine Chemical Manufacturing: Serves as a specialized intermediate for custom synthesis and contract manufacturing organizations (CMOs).

Basic Information

Item	Details
Product Name	Pregna-1,4-Dien-3-One, 9-Fluoro-11,17,20,21-Tetrahydroxy-16-Methyl-, (11β,16α)- (9Ci)
CAS No.	55879-48-6
Molecular Formula	C₂₂H₂₉FO₆
Molecular Weight	408.46 g/mol
Synonyms	9α-Fluoro-11β,17α,20β,21-tetrahydroxy-16α-methylpregna-1,4-diene-3-one; 9-Fluoro-11β,17,20,21-tetrahydroxy-16α-methylpregna-1,4-dien-3-one; 16α-Methyl-9α-fluoroprednisolone; Fluoroprednisolone 16α-methyl derivative; (11β,16α)-9-Fluoro-11,17,20,21-tetrahydroxy-16-methylpregna-1,4-dien-3-one
EINECS	Contact for details

Quality Control

Our Pregna-1,4-Dien-3-One, 9-Fluoro-11,17,20,21-Tetrahydroxy-16-Methyl-, (11β,16α)- (9Ci) is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, IR, and NMR, to ensure high chemical purity and identity confirmation, meeting the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.