Description

6-Hydroxydexamethasone is a key synthetic steroid derivative and an important metabolite of the potent glucocorticoid dexamethasone. This compound is of significant value in pharmaceutical research and development, serving as a critical reference standard and a versatile synthetic intermediate. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for analytical method development, metabolic studies, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis (e.g., HPLC, LC-MS) of dexamethasone and its metabolites in drug substances, finished products, and biological matrices.
• Metabolic Pathway Research: Serves as a crucial marker in pharmacokinetic and pharmacodynamic studies to understand the biotransformation and clearance of dexamethasone.
• Active Pharmaceutical Ingredient (API) Intermediate: Employed in the multi-step synthesis of dexamethasone and other structurally related corticosteroid drugs.
• Biochemical Research: Used as a tool compound to investigate glucocorticoid receptor (GR) interactions, signaling pathways, and the biological effects of hydroxylated steroid metabolites.
• Quality Control & Assurance: Essential for developing and validating analytical methods to ensure the purity, potency, and safety of corticosteroid-based pharmaceuticals.

Basic Information

Product Name	6-Hydroxydexamethasone
CAS No.	55879-47-5
Molecular Formula	C22H29FO6
Molecular Weight	408.46 g/mol
Synonyms	9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 6-ol; 6-Hydroxy Dexamethasone; 6-OH-Dexamethasone; Dexamethasone 6-hydroxy metabolite; 16α-Methyl-9α-fluoro-1,4-pregnadiene-11β,17α,21-triol-3,20-dione 6-ol
EINECS	Contact for details

Quality Control

Our 6-Hydroxydexamethasone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.