Description

3-Cyano-Alpha,α-Difluorotoluene (3-Cyanobenzal Fluoride) is a versatile aromatic nitrile building block distinguished by its difluoromethyl substituent. This compound is valued for its role as a key intermediate in the synthesis of advanced pharmaceutical and agrochemical agents, where its unique fluorine and nitrile functionalities enable precise molecular modifications. It is primarily sought by R&D chemists and process development teams in the fine chemical, pharmaceutical, and advanced material sectors for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the production of novel herbicides and pesticides, where the difluoromethyl group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials, contributing to improved performance in display and lighting technologies.
• Organic Synthesis Reagent: Employed in cross-coupling reactions and as a precursor for other functional groups like carboxylic acids and amides via nitrile transformation.
• Fluorine Chemistry Research: Essential for academic and industrial research exploring new fluorination methodologies and the properties of fluorinated aromatic systems.

Basic Information

Product Name	3-Cyano-Alpha,α-Difluorotoluene
CAS No.	55805-13-5
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	3-Cyanobenzal Fluoride; 3-(Difluoromethyl)benzonitrile; α,α-Difluoro-m-tolunitrile; m-(Difluoromethyl)benzonitrile; 3-(Difluoromethyl)benzonitrile; Benzonitrile, 3-(difluoromethyl)-; 55805-13-5; 3-Cyanobenzylidene Difluoride
EINECS	Contact for details

Quality Control

Our 3-Cyano-Alpha,α-Difluorotoluene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed to minimize exposure to atmospheric moisture and light to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.