Description

4-(Difluoromethyl)Benzonitrile is a versatile aromatic nitrile derivative featuring a difluoromethyl substituent, a key structural motif in modern synthetic chemistry. This compound is valued for its role as a crucial advanced pharmaceutical intermediate and a building block for agrochemicals, enabling the introduction of fluorine atoms to enhance the biological activity and metabolic stability of target molecules. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for synthesizing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral drug candidates.
• Agrochemical Synthesis: Serves as a building block for novel herbicides, fungicides, and insecticides, where the difluoromethyl group can improve efficacy and environmental profile.
• Liquid Crystal Materials: Used in the research and production of fluorinated liquid crystals for advanced display technologies.
• Organic Electronic Materials: Acts as a precursor for electron-transport materials and semiconductors in OLEDs and organic photovoltaics.
• Fluorinated Polymer Modifiers: Employed to introduce fluorine into polymer chains, enhancing properties like chemical resistance, thermal stability, and surface characteristics.
• Cross-Coupling Reactions: The nitrile and aryl halide functionalities make it a valuable substrate in Suzuki, Heck, and other palladium-catalyzed coupling reactions.

Basic Information

Product Name	4-(Difluoromethyl)Benzonitrile
CAS No.	55805-10-2
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	p-(Difluoromethyl)benzonitrile; 4-(Difluoromethyl)benzonitrile; α,α-Difluoro-p-tolunitrile; 4-Cyano-α,α-difluorotoluene; Benzonitrile, 4-(difluoromethyl)-; 1-Cyano-4-(difluoromethyl)benzene; (4-Cyanophenyl)difluoromethane; p-Cyanobenzylidene difluoride
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethyl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and IR spectroscopy to ensure high chemical purity and identity confirmation. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical parameters. Our quality commitment aligns with cGMP and ISO 9001 standards where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.