Description

4-(1,1-Difluoroethyl)Benzonitrile is a high-value, fluorinated aromatic nitrile building block. This compound is essential for the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its difluoroethyl group introduces unique electronic and steric properties. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel molecules with enhanced biological activity and material characteristics.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides with improved efficacy and environmental profiles.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in advanced display technologies.
• Organic Electronics: Employed in the synthesis of electron-transport materials and semiconductors for OLEDs and organic photovoltaics.
• Fluorinated Polymer Research: Acts as a monomer or modifier to introduce fluorine into polymer backbones, enhancing chemical resistance and thermal stability.
• Cross-Coupling Reactions: A versatile substrate for Suzuki, Heck, and other palladium-catalyzed coupling reactions to build complex biaryl structures.

Basic Information

Product Name	4-(1,1-Difluoroethyl)Benzonitrile
CAS No.	55805-05-5
Molecular Formula	C9H7F2N
Molecular Weight	167.16 g/mol
Synonyms	p-(1,1-Difluoroethyl)benzonitrile; 4-(1,1-Difluoroethyl)benzonitrile; 1-(4-Cyanophenyl)-1,1-difluoroethane; Benzonitrile, 4-(1,1-difluoroethyl)-; α,α-Difluoro-p-ethylbenzonitrile; 4-Cyanobenzene-1-(1,1-difluoroethane)
EINECS	Contact for details

Quality Control

We maintain a rigorous quality management system to ensure batch-to-batch consistency and high purity. Our standard grade for 4-(1,1-Difluoroethyl)Benzonitrile typically meets a purity specification of ≥97% (by HPLC), with detailed impurity profiling available. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for identity, assay, and specific impurities. Custom synthesis and higher purity grades (≥98%, ≥99%) are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.