Description

Bleomycin A5 Hydrochloride is a potent glycopeptide antibiotic and antitumor agent derived from *Streptomyces verticillus*. This compound is a critical active pharmaceutical ingredient (API) valued for its ability to induce single- and double-strand breaks in DNA, making it a cornerstone in specific chemotherapeutic regimens. It is essential for pharmaceutical manufacturers and research institutions developing treatments for squamous cell carcinomas, lymphomas, and testicular cancers, as well as for biochemical research into DNA cleavage mechanisms.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable chemotherapeutic formulations for treating various malignancies.
• Oncology Research: A vital tool in preclinical and clinical cancer research to study mechanisms of DNA damage and cell death.
• Biochemical Studies: Used in molecular biology laboratories to investigate DNA-protein interactions and the effects of strand scission.
• Reference Standard: Serves as a high-purity analytical standard for quality control testing in pharmaceutical production and regulatory compliance.
• Drug Discovery: Employed in screening assays and combination therapy studies to evaluate new anticancer agents.

Basic Information

Product Name	Bleomycin A5 Hydrochloride
CAS No.	55658-47-4
Molecular Formula	C55H84N17O21S2·HCl
Molecular Weight	Approx. 1448.0 g/mol (Free base: 1411.5)
Synonyms	Bleomycin A5 HCl; Pingyangmycin Hydrochloride; Bleomycin Hydrochloride A5; ZL-59A; Bleomycin A5; N1-[3-(Dimethylsulfonio)propyl]bleomycinamide Hydrochloride; Antibiotic ZL-59 A Hydrochloride; Bleomycin A5 (Hydrochloride)
EINECS	Contact for details

Quality Control

Our Bleomycin A5 Hydrochloride is manufactured and tested under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and potency, to ensure it meets stringent specifications suitable for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
pH (1% Solution)	4.0 - 6.0
Related Substances (HPLC)	Total impurities ≤ 3.0%
Bacterial Endotoxins	< 5.0 EU/mg
Sterility (if applicable)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.