Description

S-[11Beta,17-Dihydroxypregn-4-Ene-3,20-Dione] 21-(Thiopivalate) is a high-purity synthetic steroid derivative, specifically a thioester of a corticoid, valued for its role as a critical pharmaceutical intermediate. This compound is essential for researchers and manufacturers developing advanced corticosteroid-based therapeutics, where precise chemical structure and purity are paramount for efficacy and safety. It is primarily utilized in the pharmaceutical industry for the synthesis and research of novel anti-inflammatory and immunosuppressive agents.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent corticosteroid drugs.
• Anti-inflammatory Drug Research: Used in R&D for developing new topical and systemic anti-inflammatory medications.
• Immunosuppressant Development: Serves as a precursor in the creation of agents that modulate the immune system.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Metabolic Studies: Utilized in pharmacological research to study steroid metabolism and structure-activity relationships (SAR).
• Process Chemistry: Integral to scale-up and process optimization for the commercial manufacturing of steroid APIs.

Basic Information

Product Name	S-[11Beta,17-Dihydroxypregn-4-Ene-3,20-Dione] 21-(Thiopivalate)
CAS No.	55560-96-8
Molecular Formula	C₂₆H₃₈O₅S
Molecular Weight	462.64 g/mol
Synonyms	21-(Thiopivaloyloxy)-11β,17-dihydroxypregn-4-ene-3,20-dione; 11β,17-Dihydroxy-21-[(2,2-dimethylpropanoyl)thio]pregn-4-ene-3,20-dione; S-(11β,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl) 2,2-dimethylpropanethioate; Corticosteroid thioester intermediate; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 21-thiopivalate; Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-[(2,2-dimethyl-1-oxopropyl)thio]-, (11β)-
EINECS	Contact for details

Quality Control

Every batch of S-[11Beta,17-Dihydroxypregn-4-Ene-3,20-Dione] 21-(Thiopivalate) is manufactured and tested under strict quality management systems. We ensure compliance with ICH guidelines and relevant pharmaceutical intermediate standards. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to guarantee identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.