Description

n-Methyl-n-Trifluoroacetylglycine (S)-1-Methylpropyl Ester is a specialized chiral building block and fluorinated intermediate of significant interest in advanced organic synthesis. Its value lies in the combination of the trifluoroacetyl protecting group and the defined (S)-1-methylpropyl ester moiety, which are critical for introducing stereochemistry and fluorine atoms into target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and other high-value fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel fluorinated drug candidates, including protease inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced, fluorinated pesticides and herbicides where the introduction of fluorine enhances biological activity and environmental stability.
• Peptide Chemistry: Serves as a protected glycine derivative in the synthesis of modified peptides, leveraging the trifluoroacetyl group for temporary amine protection.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to construct complex molecules with high enantiomeric purity.
• Material Science Research: Utilized in the development of fluorinated organic materials and liquid crystals, where its specific steric and electronic properties are beneficial.
• Chemical Reference Standard: Acts as a high-purity standard for analytical method development and quality control in chemical manufacturing processes.

Basic Information

Product Name	n-Methyl-n-Trifluoroacetylglycine (S)-1-Methylpropyl Ester
CAS No.	55133-80-7
Molecular Formula	C9H14F3NO3
Molecular Weight	241.21 g/mol
Synonyms	(S)-1-Methylpropyl 2-(Methyl(trifluoroacetyl)amino)acetate; N-Methyl-N-trifluoroacetylglycine (S)-sec-Butyl Ester; Glycine, N-methyl-N-(trifluoroacetyl)-, (S)-1-methylpropyl ester; (S)-sec-Butyl 2-(Methyl(trifluoroacetyl)amino)acetate; N-Trifluoroacetylsarcosine (S)-sec-Butyl Ester; (S)-1-Methylpropyl N-Methyl-N-(trifluoroacetyl)glycinate; MTAG-SBE; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our n-Methyl-n-Trifluoroacetylglycine (S)-1-Methylpropyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity (enantiomeric excess) and chemical purity determination by HPLC, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its highly volatile nature and sensitivity to strong alkali/fluoride conditions, ensure the container is kept tightly sealed when not in use and stored separately from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.