Description

Tamoxifen Citrate is the citrate salt form of the selective estrogen receptor modulator (SERM) tamoxifen, a cornerstone therapeutic agent in oncology. Its primary value lies in its potent anti-estrogenic activity, which is critical for managing hormone-receptor-positive breast cancers in both pre- and post-menopausal women. This active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers developing oral dosage forms for chemotherapy and chemoprevention protocols.

Application

• Pharmaceutical API: Primary use as the active ingredient in tablet and capsule formulations for the treatment of estrogen receptor-positive (ER+) breast cancer.
• Adjuvant Therapy: Used following primary treatments like surgery or radiation to reduce the risk of cancer recurrence.
• Metastatic Cancer Treatment: Employed in the management of advanced or metastatic breast cancer.
• Chemoprevention: For high-risk individuals to reduce the incidence of developing breast cancer.
• Male Breast Cancer: A treatment option for hormone-receptor-positive breast cancer in men.
• Research & Development: Used in biochemical and pharmacological research to study estrogen receptor pathways and SERM mechanisms.
• Reference Standard: Serves as a high-purity analytical standard for quality control testing in pharmaceutical laboratories.

Basic Information

Item	Details
Product Name	Tamoxifen Citrate
CAS No.	54965-24-1
Molecular Formula	C32H37NO8
Molecular Weight	563.65 g/mol
Synonyms	Tamoxifen Citrate; (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate; ICI 46474; Nolvadex; Soltamox; Trans-Tamoxifen Citrate; Z-Tamoxifen Citrate; Tamoxifen 2-Hydroxy-1,2,3-propanetricarboxylate
EINECS	259-414-9

Quality Control

Our Tamoxifen Citrate is manufactured under strict quality management systems. It is tested to meet or exceed relevant pharmacopeial standards, including USP and EP monographs, ensuring identity, purity, strength, and composition. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15°C and 25°C. Due to its hygroscopic nature, the container must be kept in a dry environment. Keep away from excessive heat and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	-0.10° to +0.10° (in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.