Description

Chlorpheniramine CAS NO 54842-27-2 is a first-generation alkylamine antihistamine, widely recognized for its potent H1-receptor antagonism. This compound is a critical active pharmaceutical ingredient (API) essential for manufacturing effective allergy and cold relief medications. It is primarily required by pharmaceutical manufacturers, contract development and manufacturing organizations (CDMOs), and research institutions globally.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihistamine tablets, syrups, and injectables for treating allergic conditions like hay fever, urticaria, and allergic rhinitis.
• Over-the-Counter (OTC) Medications: Key component in multi-symptom cold, flu, and allergy relief formulations, often combined with analgesics and decongestants.
• Veterinary Pharmaceuticals: Used in antihistamine preparations for managing allergic reactions and pruritus in animals.
• Clinical Research: Serves as a reference standard and a tool for pharmacological studies related to histamine pathways and allergic response mechanisms.
• Generic Drug Manufacturing: Essential for producing cost-effective generic versions of branded antihistamine drugs, ensuring wider accessibility.

Basic Information

Product Name	Chlorpheniramine
CAS No.	54842-27-2
Molecular Formula	C16H19ClN2
Molecular Weight	274.79 g/mol
Synonyms	Chlorpheniramine Maleate (common salt form); Chlorphenamine; 1-(4-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane; Piriton; Chlor-Trimeton; Aller-Chlor; Teldrin; Histafen; Phenetron; CPM
EINECS	259-365-5

Quality Control

Our Chlorpheniramine is manufactured under strict quality management systems. It undergoes comprehensive analytical testing to meet or exceed relevant pharmacopeial standards such as USP, EP, and BP. A detailed Certificate of Analysis (COA) is provided with each batch, confirming identity, purity, and compliance with stringent specifications for residual solvents and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.