Description

(6α,11β,16α)-21-(Acetyloxy)-9-Bromo-6-Fluoro-11-Hydroxy-16-Methyl-Pregna-1,4-Diene-3,20-Dione is a high-purity, multi-functional steroid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or reference standard for the development of novel therapeutic agents, particularly in the fields of endocrinology and anti-inflammatory drug discovery. Its unique bromo-fluoro substitution pattern makes it a valuable building block for medicinal chemists and research institutions focused on creating new molecular entities with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel corticosteroid analogs and other potent steroid-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to develop new drugs targeting hormonal pathways and inflammatory responses.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Biochemical Research: Employed in studies investigating steroid hormone receptor binding, metabolism, and signal transduction mechanisms.
• Process Development: Utilized in the optimization and scale-up of synthetic routes for complex steroid molecules within R&D and pilot plant settings.

Basic Information

Product Name	(6α,11β,16α)-21-(Acetyloxy)-9-Bromo-6-Fluoro-11-Hydroxy-16-Methyl-Pregna-1,4-Diene-3,20-Dione
CAS No.	54604-73-8
Molecular Formula	C₂₄H₂₈BrFO₆
Molecular Weight	511.39 g/mol
Synonyms	9-Bromo-6-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate; 9-Bromo-6-fluoro-11β-hydroxy-16α-methyl-21-acetoxypregna-1,4-diene-3,20-dione; 9-Bromo-6-fluorotriamcinolone acetonide 21-acetate; 9-Bromo-6-fluoro-16α-methylprednisolone 21-acetate; Halogenated Triamcinolone Acetonide Derivative; Bromofluoro Corticosteroid Intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (6α,11β,16α)-21-(Acetyloxy)-9-Bromo-6-Fluoro-11-Hydroxy-16-Methyl-Pregna-1,4-Diene-3,20-Dione is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with cGMP guidelines for pharmaceutical intermediates and can provide material meeting specific customer specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.