Description

(+/-)-Bufuralol Hydrochloride CAS NO 54340-62-4 is a high-purity chemical compound primarily utilized as a key intermediate and reference standard in pharmaceutical research and development. Its significance lies in its role as a β-adrenergic receptor blocking agent, making it a critical material for studying cardiovascular pharmacology and metabolic pathways. This product is essential for pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug discovery, analytical method development, and quality control of related active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of more complex β-blocker drug candidates and related pharmacologically active molecules.
• Analytical Reference Standard: Used for method validation, calibration, and quantification in High-Performance Liquid Chromatography (HPLC), Liquid Chromatography-Mass Spectrometry (LC-MS), and other analytical techniques.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate β-adrenergic receptor binding, inhibition, and associated cardiovascular effects.
• Metabolite Studies: Acts as a substrate or reference compound for studying the metabolic pathways and pharmacokinetics of bufuralol and related compounds.
• Quality Control (QC) & Quality Assurance (QA): Provides a certified standard for the identity, purity, and assay testing of pharmaceutical raw materials and finished products.

Basic Information

Item	Details
Product Name	(+/-)-Bufuralol Hydrochloride
CAS No.	54340-62-4
Molecular Formula	C16H25NO2 • HCl
Molecular Weight	299.84 g/mol
Synonyms	1-(2-tert-Butylamino-1-hydroxyethyl)-7-ethylindole hydrochloride; Bufuralol HCl; (±)-Bufuralol Hydrochloride; DL-Bufuralol Hydrochloride; Ro 3-4787/001; 7-Ethyl-1-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1H-indole hydrochloride; 7-Ethyl-α-[(tert-butylamino)methyl]-1H-indole-1-ethanol hydrochloride
EINECS	Contact for details

Quality Control

Our (+/-)-Bufuralol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.