Description

3-Chloro-4,5-Difluoronitrobenzene is a high-purity, multi-functional aromatic intermediate essential for advanced organic synthesis. Its unique halogenated nitrobenzene structure makes it a critical building block for constructing complex molecules in high-value industries. This compound is primarily sought after by R&D chemists and process engineers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing difluorophenyl or chloronitrobenzene motifs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the chloro and fluoro substituents enhance biological activity and stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and halogen groups facilitate substitution reactions for introducing diverse functional groups.
• Dye & Pigment Intermediate: Employed in the production of specialized, high-performance dyes and pigments requiring halogenated nitrobenzene backbones.

Basic Information

Product Name	3-Chloro-4,5-Difluoronitrobenzene
CAS No.	53780-44-2
Molecular Formula	C6H2ClF2NO2
Molecular Weight	193.54 g/mol
Synonyms	1-Chloro-2,3-difluoro-4-nitrobenzene; 2,3-Difluoro-6-nitrochlorobenzene; 3-Chloro-4,5-difluoro-1-nitrobenzene; Benzene, 1-chloro-2,3-difluoro-4-nitro-; 4-Nitro-2,3-difluorochlorobenzene; 2,3-Difluoro-1-chloro-4-nitrobenzene; 3-Chloro-2,3-difluoronitrobenzene (ambiguous); 53780-44-2
EINECS	Contact for details

Quality Control

Our 3-Chloro-4,5-Difluoronitrobenzene is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.