Description

21-Dehydro Fluocortolone is a synthetic corticosteroid derivative, serving as a key pharmaceutical intermediate in the synthesis of advanced steroid-based active pharmaceutical ingredients (APIs). Its primary value lies in enabling the development of potent anti-inflammatory and immunosuppressive medications with targeted therapeutic profiles. This compound is essential for research institutions and pharmaceutical manufacturers engaged in the development of novel topical and systemic corticosteroid treatments.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of advanced corticosteroid APIs like fluocortolone and its prodrugs.
• Anti-inflammatory Drug Research: Used in R&D for developing new topical creams, ointments, and lotions for dermatological conditions such as eczema and psoriasis.
• Immunosuppressive Agent Development: Serves as a precursor in creating compounds for managing autoimmune disorders and preventing organ transplant rejection.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for HPLC and LC-MS method development and validation.
• Metabolic Studies: Utilized in pharmacological research to study steroid metabolism pathways and structure-activity relationships (SAR).
• Veterinary Medicine: Potential use in formulating anti-inflammatory treatments for animals.

Basic Information

Product Name	21-Dehydro Fluocortolone
CAS No.	53733-52-1
Molecular Formula	C22H27FO5
Molecular Weight	390.45 g/mol
Synonyms	9α-Fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 21-Dehydrofluocortolone; 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione; Fluocortolone Impurity; 1,4-Pregnadiene-9-fluoro-16α-methyl-11β,17α,21-triol-3,20-dione; δ1-Fluocortolone; 21-Dehydro Fluocortolone
EINECS	Contact for details

Quality Control

Our 21-Dehydro Fluocortolone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and stringent control of related substances and residual solvents. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.