Description

5-Amino-2-Fluorobenzonitrile is a high-value fluorinated aromatic nitrile building block, essential for advanced organic synthesis. Its molecular structure, featuring both an amino and a fluorine substituent, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Building block for developing new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Used in the development of advanced organic materials, including liquid crystals and functional polymers.
• Dye and Pigment Intermediate: Serves as a starting material for synthesizing specialized fluorinated dyes and pigments.
• Cross-Coupling Reactions: Valuable substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) for creating complex biaryl structures.

Basic Information

Product Name	5-Amino-2-Fluorobenzonitrile
CAS No.	53312-81-5
Molecular Formula	C7H5FN2
Molecular Weight	136.13 g/mol
Synonyms	2-Fluoro-5-aminobenzonitrile; 2-Fluoro-5-cyanobenzeneamine; 5-Cyano-2-fluoroaniline; 2-Fluoro-5-cyanoaniline; Benzonitrile, 5-amino-2-fluoro-; 5-Amino-2-fluorophenyl cyanide; 2-Fluoro-5-aminophenyl cyanide
EINECS	Contact for details

Quality Control

Our 5-Amino-2-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and industrial synthesis. A Certificate of Analysis (COA) detailing specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its light-sensitive nature and propensity to be easily oxidized (store under inert atmosphere), prolonged exposure to light and air should be avoided. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	95 - 100 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.