Description

4-Amino-2-Fluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant commercial importance. Its unique structure, featuring both an amino and a fluorine substituent, makes it a versatile intermediate for synthesizing complex molecules. This compound is essential for research and production in the pharmaceutical and agrochemical industries, where it is used to create advanced active ingredients. We supply this critical intermediate with a focus on consistent quality and reliable global supply chains.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Dye & Pigment Intermediate: Employed in the manufacture of specialized dyes and pigments where the amino and cyano groups facilitate chromophore development.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) for creating complex biaryl structures.
• Research & Development: A valuable reagent for medicinal chemistry and material science research in academic and industrial laboratories.

Basic Information

Product Name	4-Amino-2-Fluorobenzonitrile
CAS No.	53312-80-4
Molecular Formula	C7H5FN2
Molecular Weight	136.13 g/mol
Synonyms	2-Fluoro-4-aminobenzonitrile; 4-Amino-2-fluorobenzonitrile; 2-Fluoro-4-cyanobenzenamine; Benzonitrile, 4-amino-2-fluoro-; 4-Cyano-3-fluoroaniline; 3-Fluoro-4-aminobenzonitrile; 2-Fluoro-4-aminobenzene carbonitrile
EINECS	Contact for details

Quality Control

Our 4-Amino-2-Fluorobenzonitrile is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure it meets the high-purity standards required for sensitive synthesis applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. Our quality commitment ensures reliable performance and batch-to-batch consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep away from heat, sparks, and open flame. For long-term storage, consider maintaining under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	95 - 100 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.