Description

Hydrocortisone Acetate is a synthetic corticosteroid ester, widely recognized for its potent anti-inflammatory and immunosuppressive properties. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and safety of finished pharmaceutical formulations. It is primarily utilized by pharmaceutical manufacturers and compounding pharmacies in the development and production of topical creams, ointments, and ophthalmic solutions for treating various skin and eye conditions.

Application

• Topical Corticosteroid Formulations: Primary active ingredient in creams, ointments, and lotions for treating eczema, dermatitis, psoriasis, and allergic rashes.
• Ophthalmic Preparations: Used in eye drops and ointments to reduce inflammation following eye surgery or to treat conditions like allergic conjunctivitis.
• Veterinary Pharmaceuticals: Incorporated into topical treatments for inflammatory skin conditions in animals.
• Compounding Pharmacy: Serves as a key raw material for customized medication preparations to meet specific patient needs.
• Anti-Itch and Hemorrhoidal Preparations: Found in over-the-counter and prescription products designed to relieve itching, swelling, and discomfort.
• Research & Development: Used as a reference standard and in preclinical studies within pharmaceutical and biochemical research.

Basic Information

Product Name	Hydrocortisone Acetate
CAS No.	53187-58-9
Molecular Formula	C23H32O6
Molecular Weight	404.50 g/mol
Synonyms	Cortisol Acetate; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 21-acetate; 17-Hydroxycorticosterone 21-acetate; Hydrocortisone 21-Acetate; NSC 47439; Compound F Acetate; Cortef Acetate; 4-Pregnene-11β,17α,21-triol-3,20-dione 21-acetate
EINECS	Contact for details

Quality Control

Our Hydrocortisone Acetate is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications, with potential compliance to USP/EP monographs. Comprehensive testing includes identification, assay, and impurity profiling. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	+158° to +165°

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.