Description

2,3,4,5-Tetrafluorophenylacetonitrile is a versatile fluorinated aromatic nitrile building block, essential for advanced organic synthesis. Its value lies in the unique reactivity of the nitrile group combined with the electron-withdrawing and steric effects of the tetrafluorophenyl ring, enabling precise molecular construction. This high-purity intermediate is critically needed by pharmaceutical, agrochemical, and specialty chemical R&D teams for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display and lighting technologies, improving performance characteristics.
• Polymer & Resin Modifiers: Incorporated to create specialty polymers with enhanced chemical resistance, thermal stability, and unique surface properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira) to build complex, fluorinated biaryl structures.
• Nitrile Transformation Chemistry: Readily converted to corresponding acids, amides, amines, or tetrazoles, expanding its utility as a multifunctional intermediate.

Basic Information

Product Name	2,3,4,5-Tetrafluorophenylacetonitrile
CAS No.	53001-74-4
Molecular Formula	C8H3F4N
Molecular Weight	189.11 g/mol
Synonyms	2,3,4,5-Tetrafluorobenzeneacetonitrile; (2,3,4,5-Tetrafluorophenyl)acetonitrile; Tetrafluorophenylacetonitrile; α-Cyano-2,3,4,5-tetrafluorotoluene; 53001-74-4; 2,3,4,5-Tetrafluorobenzyl cyanide
EINECS	Contact for details

Quality Control

Every batch of 2,3,4,5-Tetrafluorophenylacetonitrile is manufactured and tested under a strict quality management system. We guarantee high chemical purity and consistency, supported by comprehensive analytical documentation. A Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment to ensure it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container must be kept tightly closed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.