Description

Hydroxyflutamide CAS NO 52806-53-8 is a potent non-steroidal antiandrogen and the primary active metabolite of the prodrug flutamide. This compound is critical for research and development in endocrinology and oncology, specifically targeting androgen receptor pathways. It is an essential reference standard and active pharmaceutical ingredient (API) for pharmaceutical manufacturers, academic researchers, and contract research organizations (CROs) developing treatments for prostate cancer and other androgen-dependent conditions.

Application

• Pharmaceutical Active Ingredient (API): Serves as a key intermediate or reference standard in the synthesis of advanced antiandrogen therapies.
• Biomedical Research: Used as a critical tool compound in in vitro and in vivo studies to investigate androgen receptor (AR) signaling, function, and inhibition.
• Oncology R&D: Fundamental for developing and testing novel therapeutic strategies for prostate cancer and other AR-positive malignancies.
• Metabolic Studies: Employed in pharmacokinetic and pharmacodynamic research to understand the metabolism and efficacy of flutamide and related compounds.
• Reference Standard: Used in analytical laboratories for quality control (QC) and method validation via HPLC, LC-MS, or NMR.
• Endocrine Disruptor Research: Applied in environmental and toxicological studies assessing the impact of antiandrogens.

Basic Information

Product Name	Hydroxyflutamide
CAS No.	52806-53-8
Molecular Formula	C11H11F3N2O3
Molecular Weight	276.21 g/mol
Synonyms	2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide; Hydroxyflutamide; SCH 16423; Flutamide Hydroxide; Flutamide Metabolite; 4'-Nitro-3'-trifluoromethylisobutyranilide; α,α,α-Trifluoro-2-methyl-4'-nitro-m-propionotoluidide; 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
EINECS	Contact for details

Quality Control

Our Hydroxyflutamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis, to ensure it meets high-purity standards suitable for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.