Description

3-(Trifluoromethoxy)Benzonitrile is a high-purity aromatic nitrile derivative distinguished by its trifluoromethoxy substituent. This compound serves as a versatile and critical fluorinated building block in advanced organic synthesis, enabling the introduction of both the nitrile and trifluoromethoxy functional groups. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require reliable, high-quality intermediates for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in molecules targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for advanced display technologies.
• Organic Electronics: Employed in the development of novel organic semiconductors and electron-transport materials.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Sonogashira) to construct complex biaryl systems.
• Functional Material Research: Used in academic and industrial R&D for creating polymers and coatings with specific thermal and chemical resistance properties.

Basic Information

Product Name	3-(Trifluoromethoxy)Benzonitrile
CAS No.	52771-22-9
Molecular Formula	C8H4F3NO
Molecular Weight	187.12 g/mol
Synonyms	m-(Trifluoromethoxy)benzonitrile; 3-(Trifluoromethoxy)phenyl cyanide; α,α,α-Trifluoro-m-anisyl cyanide; 3-Cyanophenyl trifluoromethyl ether; Benzonitrile, 3-(trifluoromethoxy)-; 3-Trifluoromethoxybenzonitrile
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethoxy)Benzonitrile is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for fine chemical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index	1.450 - 1.455
Density	1.30 - 1.35 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.