Description

L-Proline, 4,4-Difluoro- (9Ci) is a fluorinated derivative of the amino acid L-proline, characterized by the substitution of two fluorine atoms at the 4-position of the pyrrolidine ring. This structural modification is crucial for its role as a high-value building block in medicinal chemistry and advanced organic synthesis. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, agrochemicals, and specialty biochemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of fluorinated drug candidates, including protease inhibitors and other bioactive molecules.
• Peptide Chemistry: Used to incorporate fluorinated proline residues into peptides and peptidomimetics to study and modulate their conformational stability and biological activity.
• Agrochemical Research: Serves as a precursor in the synthesis of novel, fluorinated active ingredients for crop protection products.
• Biochemical Probe Development: Utilized in creating labeled compounds and probes for studying enzyme mechanisms and metabolic pathways.
• Material Science: Investigated as a component in the synthesis of specialized polymers and advanced materials with unique properties.

Basic Information

Product Name	L-Proline, 4,4-Difluoro- (9Ci)
CAS No.	52683-81-5
Molecular Formula	C5H7F2NO2
Molecular Weight	151.11 g/mol
Synonyms	(2S)-4,4-Difluoropyrrolidine-2-carboxylic acid; 4,4-Difluoro-L-proline; L-4,4-Difluoroproline; (S)-4,4-Difluoroproline; 4,4-Difluoroproline; 52683-81-5; (S)-4,4-Difluoropyrrolidine-2-carboxylic acid; 4,4-Difluoro-(S)-proline
EINECS	Contact for details

Quality Control

Our L-Proline, 4,4-Difluoro- (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.