Description

Pyr-His-Trp-Ser-Tyr-D-Lys-Leu-Arg-Pro-Gly-Nh2 is a synthetic decapeptide amide, a potent analog of Gonadotropin-Releasing Hormone (GnRH). This compound is critical for research and development in endocrinology and reproductive medicine, offering a valuable tool for studying hormone regulation and receptor interactions. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on developing novel therapeutic agents and diagnostic assays.

Application

• Endocrine Research: A key reagent for studying the hypothalamic-pituitary-gonadal axis, GnRH receptor binding, and signal transduction mechanisms.
• Pharmaceutical Development: Serves as a reference standard and active pharmaceutical ingredient (API) intermediate in the development of fertility treatments and hormone-related therapies.
• Biochemical Assays: Used in in vitro bioassays to measure biological activity and for the calibration of analytical methods like HPLC and mass spectrometry.
• Peptide Chemistry Studies: An important compound for investigating structure-activity relationships (SAR) of GnRH analogs and peptide stability.
• Veterinary Medicine: Applied in research for animal reproduction control and fertility management.

Basic Information

Product Name	Pyr-His-Trp-Ser-Tyr-D-Lys-Leu-Arg-Pro-Gly-Nh2
CAS No.	52671-12-2
Molecular Formula	C₆₀H₈₆N₁₈O₁₄
Molecular Weight	1267.5 g/mol
Synonyms	GnRH Agonist (pGlu-His-Trp-Ser-Tyr-D-Lys-Leu-Arg-Pro-Gly-NH₂); Gonadorelin Analog; Luteinizing Hormone-Releasing Hormone (LHRH) Agonist; pGlu-His-Trp-Ser-Tyr-D-Lys-Leu-Arg-Pro-Gly-NH₂; Des-Gly10-GnRH Ethylamide (D-Lys6); [D-Lys6]-GnRH; Fertirelin Acetate (related salt form); Decapeptide Amide (GnRH).
EINECS	Contact for details

Quality Control

Our Pyr-His-Trp-Ser-Tyr-D-Lys-Leu-Arg-Pro-Gly-Nh2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are provided to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This hygroscopic and light-sensitive material should be allowed to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%
Amino Acid Composition	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Peptide Content (N)	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.