Description

9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21-(3,3-Dimethylbutyrate) is a high-purity synthetic corticosteroid derivative, specifically a 21-ester of a fluorinated glucocorticoid. This compound is of significant commercial and research interest due to its potent anti-inflammatory and immunosuppressive pharmacological profile, making it a critical intermediate in advanced pharmaceutical synthesis. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel steroid-based therapeutics, diagnostic agents, and reference standards.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potent topical and systemic corticosteroid APIs (Active Pharmaceutical Ingredients).
• Research & Development: Used in preclinical and clinical research to study glucocorticoid receptor activity, anti-inflammatory pathways, and metabolic effects.
• Reference Standard: Serves as a high-purity chemical reference material (CRM) for quality control and analytical method development in regulatory compliance.
• Biochemical Studies: Employed in molecular biology and biochemistry to investigate steroid hormone action and signal transduction mechanisms.
• Veterinary Medicine: Potential use in the development of anti-inflammatory treatments for animals.

Basic Information

Product Name	9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21-(3,3-Dimethylbutyrate)
CAS No.	52668-06-1
Molecular Formula	C₂₈H₃₉FO₇
Molecular Weight	506.61 g/mol
Synonyms	Flumethasone 21-Pivalate; Flumetasone Pivalate; 6α,9α-Difluoro-16α-methylprednisolone 21-Pivalate; 6α,9α-Difluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-Pivalate; SQ 15102; NSC-107680; Locacorten
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21-(3,3-Dimethylbutyrate) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Production can be aligned with cGMP (current Good Manufacturing Practice) guidelines for pharmaceutical intermediate applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.