Description

Betamethasone-(E)-Enolaldehyde is a key pharmaceutical intermediate and a crucial synthetic precursor in the production of corticosteroid drugs. This high-purity compound is essential for research and development in advanced pharmaceutical synthesis, enabling the creation of potent anti-inflammatory and immunosuppressive agents. It is primarily utilized by pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers focused on steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of Betamethasone and its derivatives.
• Corticosteroid Research: Used in the development and study of novel glucocorticoid receptor agonists with enhanced potency or selectivity.
• Process Chemistry: Serves as a key starting material for scaling up the production of steroid-based active pharmaceutical ingredients (APIs).
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Chemical Synthesis: Utilized in organic synthesis for introducing the steroidal enolaldehyde moiety into complex molecular architectures.

Basic Information

Product Name	Betamethasone-(E)-Enolaldehyde
CAS No.	52647-07-1
Molecular Formula	C₂₂H₂₉FO₅
Molecular Weight	392.46 g/mol
Synonyms	9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-Acetaldehyde; (E)-17-[(1S)-1-Hydroxy-2-(hydroxymethyl)-2-oxoethyl]-9-fluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-16-carbaldehyde; 16β-Methyl-9α-fluoro-δ¹,⁴-pregnadiene-11β,17α,21-triol-3,20-dione 21-Aldehyde; Betamethasone 21-Aldehyde; Betamethasone Enol Aldehyde
EINECS	Contact for details

Quality Control

Our Betamethasone-(E)-Enolaldehyde is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with the stringent requirements of pharmaceutical ingredient supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.