Description

9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21-Pivalate is a high-purity synthetic corticosteroid derivative, specifically the 21-pivalate ester of a fluorinated and methylated prednisolone analog. This compound is valued for its potent anti-inflammatory and immunosuppressive activity, serving as a critical advanced intermediate in the synthesis of modern topical and systemic pharmaceutical agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of next-generation steroid-based therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potent corticosteroid APIs (Active Pharmaceutical Ingredients).
• Research & Development: Used in preclinical and clinical research to study structure-activity relationships (SAR) of steroid molecules.
• Anti-inflammatory Drug Synthesis: Intermediate for the production of advanced topical creams, ointments, and inhalants targeting dermatological and respiratory conditions.
• Immunosuppressant Development: Serves as a precursor in creating agents for managing autoimmune diseases and preventing organ transplant rejection.
• Reference Standard: Can be utilized as an analytical standard in quality control laboratories for method development and validation.
• Process Chemistry: Employed in scaling up and optimizing manufacturing routes for complex steroid molecules under GMP conditions.

Basic Information

Product Name	9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21-Pivalate
CAS No.	52619-02-0
Molecular Formula	C₂₇H₃₇FO₆
Molecular Weight	476.58 g/mol
Synonyms	9α-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-pivalate; 16β-Methyl-9α-fluoroprednisolone 21-pivalate; 9-Fluoro-16β-methylprednisolone 21-pivalate; Fluprednisolone Pivalate; Fluprednisolone 21-trimethylacetate; 9α-Fluoro-16β-methylprednisolone 21-pivalate; NSC 47439
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21-Pivalate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.