Description

n-Trifluoroacetamido-4’-p-Nitrobenzoyl Daunorubicin is a chemically modified derivative of the anthracycline antibiotic daunorubicin, designed for advanced pharmaceutical research and development. This compound is critical for synthesizing novel drug conjugates and targeted therapies, offering researchers a versatile building block with specific reactive handles. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on oncology drug discovery and the development of antibody-drug conjugates (ADCs).

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel chemotherapeutic agents and targeted cancer therapies.
• Antibody-Drug Conjugate (ADC) Payload Synthesis: Used to construct potent cytotoxic payloads for conjugation to monoclonal antibodies, enhancing targeted drug delivery.
• Oncology Research: Serves as a critical tool in biochemical and pharmacological studies to understand structure-activity relationships (SAR) of anthracycline derivatives.
• Medicinal Chemistry: Employed in the design and synthesis of new chemical entities (NCEs) with potential anti-tumor activity.
• Bioconjugation Studies: Utilized for developing novel linker-payload systems due to its reactive functional groups.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical manufacturing.

Basic Information

Product Name	n-Trifluoroacetamido-4’-p-Nitrobenzoyl Daunorubicin
CAS No.	52583-24-1
Molecular Formula	C₃₄H₂₈F₃N₃O₁₂
Molecular Weight	727.60 g/mol
Synonyms	Daunorubicin, 3'-N-trifluoroacetyl-4'-p-nitrobenzoyl-; 3'-N-Trifluoroacetyl-4'-p-nitrobenzoyldaunorubicin; 4'-p-Nitrobenzoyl-3'-N-trifluoroacetyldaunorubicin; 3'-N-Trifluoroacetyldaunorubicin 4'-p-nitrobenzoate; Daunorubicin derivative (C-3' N-trifluoroacetyl, C-4' p-nitrobenzoyl); TFA-Nitrobenzoyl Daunorubicin; 52583-24-1; Daunorubicin trifluoroacetamido nitrobenzoyl analog
EINECS	Contact for details

Quality Control

Our n-Trifluoroacetamido-4’-p-Nitrobenzoyl Daunorubicin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The material is moisture-sensitive; ensure the container is sealed and stored in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	Orange to red solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.