Description

Arotinolol is a non-selective β-adrenergic receptor antagonist (β-blocker) with intrinsic sympathomimetic activity. This compound is a key pharmaceutical intermediate and active pharmaceutical ingredient (API) in the research and development of cardiovascular therapeutics. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the synthesis of novel β-blockers for clinical studies. The material is supplied as a high-purity chemical substance, with CAS No. 52560-77-7, to support critical drug development and production processes.

Application

• Pharmaceutical API Synthesis: Primary use as an active pharmaceutical ingredient in the manufacture of β-blocker medications.
• Cardiovascular Research: Critical intermediate in preclinical and clinical research for hypertension and angina pectoris treatments.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Process Development: Used in the development and scale-up of synthetic routes for β-adrenergic antagonists.
• Formulation Studies: Employed in the development of various drug delivery systems, including tablets and controlled-release formulations.
• Metabolite Studies: Utilized in pharmacokinetic and metabolic pathway research to understand drug behavior in biological systems.

Basic Information

Product Name	Arotinolol
CAS No.	52560-77-7
Molecular Formula	C15H21N3O3S2
Molecular Weight	371.48 g/mol
Synonyms	5-[2-[(3-tert-Butylamino-2-hydroxypropyl)thio]-4-thiazolyl]-2-thiophenecarboxamide; Almarl (brand name); Arotinolol Hydrochloride (salt form); (±)-Arotinolol; AR-L; β-adrenergic blocking agent
EINECS	Contact for details

Quality Control

Our Arotinolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical intermediates, including identity, purity, and impurity profile. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for key parameters such as assay, related substances, residual solvents, and heavy metals. We adhere to cGMP principles where applicable to support our global clientele in regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.