Description

Prednisolone is a synthetic glucocorticoid, a potent anti-inflammatory and immunosuppressive agent derived from cortisol. This compound is critical for its rapid onset of action and high bioavailability, making it a cornerstone in therapeutic formulations. It is essential for pharmaceutical manufacturers and research institutions developing treatments for inflammatory conditions, autoimmune disorders, and certain cancers.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the manufacture of oral tablets, injectables, and topical formulations for treating inflammation, allergies, and autoimmune diseases like rheumatoid arthritis and lupus.
• Veterinary Medicine: Used in anti-inflammatory and immunosuppressive therapies for companion animals and livestock.
• Clinical Research: Serves as a reference standard and key intermediate in pharmacological studies and drug development programs.
• Ophthalmic Preparations: Formulated into eye drops and ointments to treat severe ocular inflammation and uveitis.
• Dermatological Creams & Ointments: Incorporated into topical products for managing skin conditions such as eczema, psoriasis, and contact dermatitis.
• Oncological Supportive Care: Employed to manage side effects like nausea and inflammation in certain chemotherapy regimens.

Basic Information

Product Name	Prednisolone
CAS No.	52438-85-4
Molecular Formula	C21H28O5
Molecular Weight	360.44 g/mol
Synonyms	1,4-Pregnadiene-11β,17α,21-triol-3,20-dione; 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione; Delta1-Hydrocortisone; Metacortandralone; Prednisolonum; NSC-9900; Cortalone; Hydeltra; Precortalon; Sterane
EINECS	257-905-8

Quality Control

Our Prednisolone is manufactured under strict quality management systems. It can be supplied in grades compliant with USP, Ph. Eur., and BP monographs, ensuring it meets the rigorous standards for pharmaceutical applications. Every batch undergoes comprehensive analytical testing, including identity, purity, and impurity profile verification. Certificates of Analysis (COA) are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to almost white, crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Specific Optical Rotation	+97° to +103°
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.