Description

Ketotrexate CAS NO 52196-22-2 is a high-purity chemical compound of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or active pharmaceutical ingredient (API) for the synthesis of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical suppliers engaged in the development of targeted drug therapies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard or reagent in laboratory studies investigating metabolic pathways and enzyme interactions.
• Antifolate Agent Development: Acts as a core structure for research into novel antifolate compounds with potential therapeutic applications.
• Oncology Research: Investigated for its role in the development of chemotherapeutic agents targeting specific cellular processes.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for producing specialized, high-value chemical entities.

Basic Information

Product Name	Ketotrexate
CAS No.	52196-22-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Ketotrexate; 5-Methyl-5,6,7,8-tetrahydrofolic acid; 5-Methyl-5,6,7,8-tetrahydropteroylglutamic acid; 5-Methyl THFA; 5-Methyltetrahydrofolic acid (common mis-association); L-Ketotrexate; NSC-113928; (S)-Ketotrexate
EINECS	Contact for details

Quality Control

Our Ketotrexate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay and impurity profiles. Our quality commitment aligns with cGMP principles where applicable for pharmaceutical-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.