Description

11β,17,21-Trihydroxy-16α-Methylpregna-1,4,8-Triene-3,20-Dione is a synthetic corticosteroid derivative, a key intermediate in the pharmaceutical synthesis of potent anti-inflammatory and immunosuppressive agents. Its value lies in providing a high-purity, structurally defined building block essential for the reliable and scalable production of advanced steroid-based pharmaceuticals. This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development and production of specialized corticosteroid medications.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of advanced corticosteroid drugs, such as dexamethasone and related analogs.
• Anti-inflammatory Drug Research: Serves as a key structural scaffold in medicinal chemistry for developing new glucocorticoid receptor agonists with improved efficacy and safety profiles.
• Immunosuppressant Synthesis: Used in the production pathway for medications designed to modulate immune system responses in autoimmune diseases and organ transplantation.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for the identification and quantification of active pharmaceutical ingredients (APIs) and related substances.
• Process Development: Utilized in process chemistry research to optimize synthetic routes, improve yields, and ensure the robustness of steroid manufacturing processes.

Basic Information

Product Name	11β,17,21-Trihydroxy-16α-Methylpregna-1,4,8-Triene-3,20-Dione
CAS No.	52092-04-3
Molecular Formula	C22H28O5
Molecular Weight	372.46 g/mol
Synonyms	9α-Fluoro-16α-methylprednisolone; 9α-Fluoro-16α-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione; 9-Fluoro-16α-methylprednisolone; 16α-Methyl-9α-fluoroprednisolone; 9α-Fluoro-16α-methyl-δ1,4-pregnadiene-11β,17α,21-triol-3,20-dione; Fluormethylprednisolone; NSC 47439
EINECS	Contact for details

Quality Control

Our 11β,17,21-Trihydroxy-16α-Methylpregna-1,4,8-Triene-3,20-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.