Description

Chloroprednisone is a synthetic corticosteroid derivative, specifically a chlorinated analog of prednisone. This compound is of significant interest in pharmaceutical research and development for its potent anti-inflammatory and immunosuppressive properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel steroid-based therapeutics. Chloroprednisone CAS NO 52080-57-6 serves as a key intermediate or reference standard in the synthesis and analytical validation of advanced corticosteroid drugs.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of advanced corticosteroid medications.
• Biochemical Research: Used in laboratory studies to investigate steroid receptor binding, metabolic pathways, and structure-activity relationships (SAR).
• Reference Standard: Serves as a high-purity analytical standard for quality control (QC) and method development in pharmaceutical analysis using HPLC, LC-MS, or NMR.
• Anti-inflammatory Agent Development: A precursor molecule for creating new therapeutic agents targeting chronic inflammatory and autoimmune conditions.
• Metabolite Studies: Employed in research to understand the biotransformation and pharmacokinetics of chlorinated steroids.

Basic Information

Product Name	Chloroprednisone
CAS No.	52080-57-6
Molecular Formula	C21H25ClO5
Molecular Weight	392.87 g/mol
Synonyms	9α-Chloro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione; 9α-Chloroprednisolone; 9α-Chloro-δ1-hydrocortisone; Chloroprednisolone; NSC-92336; 9α-Chloro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione; 9α-Chloro-17α,21-dihydroxypregna-1,4-diene-3,11,20-trione
EINECS	Contact for details

Quality Control

Our Chloroprednisone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research materials. Certificates of Analysis (COA) detailing results for assay, related substances, and residual solvents are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.