Description

Triprolidine Hydrochloride Z-Isomer is a specific stereoisomeric form of the well-known antihistamine compound. This high-purity isomer is critical for pharmaceutical research and development, particularly in the study of structure-activity relationships and the production of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily sought by pharmaceutical manufacturers, advanced R&D laboratories, and fine chemical suppliers focused on producing or studying chiral drug substances to ensure efficacy and minimize side effects.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of enantiomerically pure antihistamine APIs.
• Analytical Reference Standard: Used as a high-purity standard in HPLC, LC-MS, and other chromatographic methods for quality control and method development.
• Pharmacological Research: Essential for studying the stereoselective binding, metabolism, and pharmacokinetic profile of triprolidine.
• Process Development & Optimization: Employed in scaling up and optimizing asymmetric synthesis routes in fine chemical production.
• Regulatory Submissions: Serves as a characterized material for drug master files (DMFs) and regulatory documentation.

Basic Information

Product Name	Triprolidine Hydrochloride Z-Isomer
CAS No.	51657-91-1
Molecular Formula	C19H22N2·HCl
Molecular Weight	314.85 g/mol
Synonyms	(Z)-Triprolidine Hydrochloride; (E)-1-(4-Methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene Hydrochloride (Z-isomer); cis-Triprolidine Hydrochloride; Triprolidine HCl (Z-Form); 51657-91-1; Triprolidine (Z-isomer) Hydrochloride
EINECS	Contact for details

Quality Control

Our Triprolidine Hydrochloride Z-Isomer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and isomer content.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Isomeric Purity (Z-Isomer)	≥99.0%
Water (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.