Description

(R)-Budesonide is the single enantiomer form of the potent glucocorticoid steroid, budesonide. This high-purity isomer is critical for advanced pharmaceutical research and development, particularly in studying stereospecific biological activity and receptor binding. It is primarily utilized by research institutions and pharmaceutical companies focused on developing targeted anti-inflammatory and immunosuppressive therapies, including next-generation inhalable treatments for asthma and COPD.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for analytical method development, validation, and quality control testing of budesonide-based drug products.
• Stereochemistry Research: Used in preclinical studies to investigate the distinct pharmacokinetic and pharmacodynamic profiles of the (R)-enantiomer compared to the racemic mixture or (S)-enantiomer.
• Active Pharmaceutical Ingredient (API) Development: A key intermediate in the synthesis and development of enantiomerically pure corticosteroid medications.
• Mechanism of Action Studies: Employed in biochemical assays to study glucocorticoid receptor binding affinity and the subsequent anti-inflammatory pathways with high specificity.
• Formulation Research: Used in the development and testing of novel drug delivery systems, such as metered-dose inhalers (MDIs), dry powder inhalers (DPIs), and nasal sprays.
• Impurity Profiling: Acts as a critical marker for identifying and quantifying enantiomeric impurities in racemic budesonide batches during API manufacturing.

Basic Information

Product Name	(R)-Budesonide
CAS No.	51372-29-3
Molecular Formula	C25H34O6
Molecular Weight	430.53 g/mol
Synonyms	(R)-Budesonide; (11β,16α)-Budesonide; 16α,17-[(1R)-Butylidenebis(oxy)]-11β,21-dihydroxypregna-1,4-diene-3,20-dione; Ent-Budesonide; Dexbudesonide; (R)-Enantiomer of Budesonide; 16α,17α-22R, S-Butylmethylenedioxy-11β,21-dihydroxy-1,4-pregnadiene-3,20-dione; Pulmicort (related to racemic product)
EINECS	Contact for details

Quality Control

Our (R)-Budesonide is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical research. A Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and related substances is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% (R)-enantiomer
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.