Description

21-[3-(Benzoylamino)-2-Methyl-1-Oxopropoxy]-16,17-[[[4-(Dimethylamino)Phenyl]Methylene]Bis(Oxy)]-9-Fluoro-11-Hydroxypregna-1,4-Diene-3,20-Dione is a complex synthetic corticosteroid derivative of significant interest in advanced pharmaceutical research and development. This compound matters as a key high-purity intermediate for synthesizing novel anti-inflammatory and immunosuppressive agents, offering researchers a precise building block for drug discovery. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers developing next-generation steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel corticosteroid drugs targeting inflammation and autoimmune disorders.
• Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies to develop new therapeutic entities.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Biochemical Research: Utilized in studies investigating glucocorticoid receptor interactions and downstream signaling pathways.
• Process Chemistry: Acts as a key intermediate in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Item	Detail
Product Name	21-[3-(Benzoylamino)-2-Methyl-1-Oxopropoxy]-16,17-[[[4-(Dimethylamino)Phenyl]Methylene]Bis(Oxy)]-9-Fluoro-11-Hydroxypregna-1,4-Diene-3,20-Dione
CAS No.	51241-99-7
Molecular Formula	C41H45FN2O8
Molecular Weight	712.81 g/mol
Synonyms	9-Fluoro-11β,21-dihydroxy-16α,17α-[(4-dimethylaminophenyl)methylene]bis(oxy)pregna-1,4-diene-3,20-dione 21-(3-Benzamido-2-methylpropionate); 9-Fluoro-11β-hydroxy-16α,17α-[(4-dimethylaminophenyl)methylene]bis(oxy)pregna-1,4-diene-3,20-dione 21-(3-Benzamido-2-methylpropionate); Difluprednate Impurity; Difluprednate Related Compound; Corticosteroid Derivative CAS 51241-99-7
EINECS	Contact for details

Quality Control

Our 21-[3-(Benzoylamino)-2-Methyl-1-Oxopropoxy]-16,17-[[[4-(Dimethylamino)Phenyl]Methylene]Bis(Oxy)]-9-Fluoro-11-Hydroxypregna-1,4-Diene-3,20-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific research or compendial requirements (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.