Description

17,21-Dihydroxypregna-1,4-Diene-3,11,20-Trione 21-Pivalate is a high-purity steroid derivative and a key pharmaceutical intermediate. This compound is critical for the synthesis of advanced corticosteroid APIs, offering a defined chemical backbone for further functionalization. It is primarily required by pharmaceutical R&D laboratories and manufacturers specializing in anti-inflammatory and immunosuppressant drug development.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of potent corticosteroid active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for the development and structural modification of new steroid-based therapeutic agents.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of steroid drugs.
• Biochemical Research: Utilized in studies investigating steroid hormone pathways, receptor binding, and metabolic processes.

Basic Information

Product Name	17,21-Dihydroxypregna-1,4-Diene-3,11,20-Trione 21-Pivalate
CAS No.	51192-49-5
Molecular Formula	C₂₆H₃₄O₇
Molecular Weight	458.55 g/mol
Synonyms	Prednisolone 21-Pivalate; 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione 21-Pivalate; Prednisolone Pivalate; 1,4-Pregnadiene-11β,17α,21-triol-3,20-dione 21-Pivalate; 11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-Pivalate; Pivalic Acid Prednisolone Ester; NSC 106977; SQ 15102
EINECS	Contact for details

Quality Control

Our 17,21-Dihydroxypregna-1,4-Diene-3,11,20-Trione 21-Pivalate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and specific tests for residual solvents and related substances. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.