Description

9-Fluoro-11Beta,21-Dihydroxy-16Alpha,17-(Isopropylidenedioxy)Pregna-1,4-Diene-3,20-Dione 21-Valerate is a high-purity synthetic corticosteroid derivative, specifically a fluorinated pregnadiene with a valerate ester group. This compound is a critical advanced pharmaceutical intermediate valued for its potent anti-inflammatory and immunosuppressive activity. It is primarily required by pharmaceutical R&D and manufacturing sectors for the development and production of specialized topical and systemic corticosteroid medications.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potent topical corticosteroids like fluticasone valerate and related analogs.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structure for research into new anti-inflammatory and immunosuppressive drugs.
• Dermatological Formulations: Used in the development of creams, ointments, and lotions for treating eczema, psoriasis, and dermatitis.
• Respiratory Medicine: Investigated for use in inhaled corticosteroid formulations for asthma and COPD management.
• Process Chemistry & Scale-Up: Employed in process optimization and pilot-scale manufacturing for GMP production.
• Reference Standard: Serves as an analytical standard for quality control and regulatory compliance testing in API manufacturing.
• Biochemical Research: Used in studies of glucocorticoid receptor binding and steroid hormone action mechanisms.

Basic Information

Product Name	9-Fluoro-11Beta,21-Dihydroxy-16Alpha,17-(Isopropylidenedioxy)Pregna-1,4-Diene-3,20-Dione 21-Valerate
CAS No.	51112-52-8
Molecular Formula	C29H39FO7
Molecular Weight	518.62 g/mol
Synonyms	Fluticasone Valerate EP Impurity C; Fluticasone 17-Valerate Intermediate; 9-Fluoro-11β,21-dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione 21-valerate; 6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(2,2-dimethyl-1-oxobutoxy)androsta-1,4-diene-17β-carbothioic Acid S-Fluoromethyl Ester Related Compound; Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,21-dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]-, 21-valerate; 16α,17α-Isopropylidenedioxy-9α-fluoro-11β,21-dihydroxypregna-1,4-diene-3,20-dione 21-valerate
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,21-Dihydroxy-16Alpha,17-(Isopropylidenedioxy)Pregna-1,4-Diene-3,20-Dione 21-Valerate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC for purity, chiral analysis, and identification by IR and NMR to ensure compliance with pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is light-sensitive and easily oxidized; for long-term storage, consider under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.