Description

Amcinonide CAS NO 51022-69-6 is a synthetic corticosteroid belonging to the glucocorticoid class, known for its potent anti-inflammatory and immunosuppressive properties. This high-purity active pharmaceutical ingredient (API) is critical for the development of effective topical dermatological treatments. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on advanced therapeutic formulations for inflammatory skin conditions.

Application

• Topical Corticosteroid Formulations: Primary active ingredient in creams, ointments, and lotions for treating psoriasis, eczema, and dermatitis.
• Pharmaceutical Intermediates: Serves as a key synthetic intermediate in the production of more complex steroid-based APIs.
• Research & Development: Used in preclinical and clinical studies to investigate mechanisms of glucocorticoid receptor activity and new delivery systems.
• Veterinary Medicine: Incorporated into topical preparations for managing inflammatory skin disorders in animals.
• Compounding Pharmacy: Utilized by specialized pharmacies to prepare customized topical medications for specific patient needs.

Basic Information

Product Name	Amcinonide
CAS No.	51022-69-6
Molecular Formula	C28H35FO7
Molecular Weight	502.58 g/mol
Synonyms	Amcinonide; Cyclocort; Amcinafal; Amcinafide; 9α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone; (11β,16α)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone
EINECS	256-989-8

Quality Control

Our Amcinonide is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical actives. Each batch is tested against comprehensive specifications, including identity, purity, and impurity profiles, utilizing advanced analytical techniques like HPLC. Certificates of Analysis (COA) documenting full compliance are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.