Description

4-(Chloro-Difluoro-Methyl)-Benzonitrile is a versatile aromatic nitrile derivative featuring a chlorodifluoromethyl substituent. This compound serves as a critical high-value building block in advanced organic synthesis, prized for its ability to introduce functionalized aromatic motifs. It is primarily required by R&D and production chemists in the pharmaceutical and agrochemical industries for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a substituted benzonitrile core.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides.
• Liquid Crystal Materials: Serves as a building block for fluorine-containing liquid crystal compounds used in display technologies.
• Functional Material Development: Intermediate for creating specialty polymers, dyes, and organic electronic materials.
• Cross-Coupling Reactions: Valuable substrate in palladium-catalyzed reactions (e.g., Suzuki, Sonogashira) for constructing complex molecules.
• Fluorine Chemistry Research: Essential reagent for studying the effects of chlorodifluoromethyl groups on aromatic system reactivity and physical properties.

Basic Information

Product Name	4-(Chloro-Difluoro-Methyl)-Benzonitrile
CAS No.	51012-21-6
Molecular Formula	C8H4ClF2N
Molecular Weight	187.57 g/mol
Synonyms	4-(Chlorodifluoromethyl)benzonitrile; p-(Chlorodifluoromethyl)benzonitrile; α,α-Difluoro-4-cyanobenzyl chloride; 4-Cyanobenzyl chloride, α,α-difluoro-; Benzonitrile, 4-(chlorodifluoromethyl)-; 51012-21-6; 4-(Chlorodifluoromethyl)phenyl cyanide
EINECS	Contact for details

Quality Control

Our 4-(Chloro-Difluoro-Methyl)-Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and GC-MS and NMR for identity confirmation, to ensure it meets exacting R&D and production standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.