Description

(R)-Bis[3-[3-(tert-Butylamino)-2-Hydroxypropoxy]-4-Morpholino-1,2,5-Thiadiazole] Maleate is a high-purity, chiral active pharmaceutical ingredient (API) and key synthetic intermediate. This compound is valued for its specific stereochemistry and functional groups, which are critical for biological activity in advanced pharmaceutical research and development. It is primarily required by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the synthesis of novel therapeutic agents, particularly in areas requiring precise molecular targeting.

Application

• Pharmaceutical API Intermediate: A critical building block in the multi-step synthesis of proprietary drug candidates, leveraging its chiral center for desired enantiomeric purity.
• Cardiovascular Research: Used in preclinical studies and development of compounds targeting specific receptors in the cardiovascular system.
• β-Adrenergic Blocker Analog Synthesis: Serves as a sophisticated precursor in the research and development of new-generation β-blocker analogs with potential improved selectivity.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and signal transduction pathways.
• Process Chemistry & Scale-Up: Used by process chemists to develop and optimize scalable, GMP-compliant synthetic routes for clinical trial material production.
• Reference Standard: Sourced as a high-purity analytical standard for method development, validation, and quality control in regulatory filings.

Basic Information

Product Name	(R)-Bis[3-[3-(tert-Butylamino)-2-Hydroxypropoxy]-4-Morpholino-1,2,5-Thiadiazole] Maleate
CAS No.	50929-98-1
Molecular Formula	C34H58N8O10S2
Molecular Weight	802.99 g/mol
Synonyms	(R)-Timolol Maleate Dimer; (R)-Bis(4-morpholino-3-((3-((tert-butyl)amino)-2-hydroxypropoxy)-1,2,5-thiadiazole) Maleate; (R)-Timolol Related Compound; (R)-Form of Timolol Dimer Maleate; 1,2,5-Thiadiazole, 4-morpholino-3-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-, (R)-, dimer with (Z)-2-butenedioic acid; (R)-3-[[3-(tert-Butylamino)-2-hydroxypropoxy]-4-morpholino-1,2,5-thiadiazole Maleate Dimer
EINECS	Contact for details

Quality Control

Our (R)-Bis[3-[3-(tert-Butylamino)-2-Hydroxypropoxy]-4-Morpholino-1,2,5-Thiadiazole] Maleate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and reference standard applications. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and impurities is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (R)-enantiomer
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.