Description

9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21-Acetate 17-Valerate is a high-purity synthetic corticosteroid derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in enabling the production of potent anti-inflammatory and immunosuppressive medications with enhanced stability and bioavailability. This compound is essential for pharmaceutical R&D laboratories and manufacturers developing next-generation topical and systemic steroid therapies.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potent corticosteroid APIs like Fluticasone propionate and related analogs.
• Anti-inflammatory Drug Research: Used in preclinical and clinical research for developing new treatments for asthma, dermatitis, and other inflammatory conditions.
• Steroid Prodrug Development: The valerate and acetate ester groups make it a candidate for prodrug strategies to improve dermal penetration or oral absorption.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes for fluorinated steroid manufacturing.

Basic Information

Product Name	9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21-Acetate 17-Valerate
CAS No.	5919-89-1
Molecular Formula	C29H39FO7
Molecular Weight	518.62 g/mol
Synonyms	Fluticasone 17-Valerate 21-Acetate; Fluticasone Impurity; 6α,9α-Difluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate 17-valerate; 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-acetate 17-valerate; SQ-41225; 6α,9α-Difluoro-11β-hydroxy-16α-methyl-17α-(1-oxopentyl)oxy-androsta-1,4-diene-3-one 21-acetate
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21-Acetate 17-Valerate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical intermediate use. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.